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Medical depigmentation method of proven efficacy for the treatment of the most severe, resistant skin hyperpigmentations. Its dual action allows to correct visible hyperpigmentations and regulate melanin overproduction, to provide a short and long-term result.

Multiple clinical studies and thousands patients and specialists all over the world support the efficacy and safety of dermamelan® for the treatment of all types of skin hyperpigmentations and phototypes.


Melanogenesis is the biological mechanism that the body has to defend itself from the potential damage that solar radiation can cause to the cell's DNA. It consists in the production of melanin by the melanocyte, which is the innermost layer of the epidermis, and its subsequent transfer to the epidermis' keratinocytes, which are cells subject to greater exposure to solar radiation due to their superficial location. This is a complex mechanism, in which several exogenous and endogenous factors intervene (physical, biochemical and morphological factors of the skin), and the ultimate objective of which is to create a UV protective barrier in the cell nucleus.

Melanin is produced in the melanosomes (the vesicles that are transferred from the melanocyte to the keratinocyte) from the amino acid tyrosine. The enzyme tyrosinase catalyses a sequential oxidation process by means of which tyrosine transforms into the intermediate DOPA, which in turn is transformed into dopaquinone.

Sometimes, an excess of melanin can be produced due to external factors (solar radiation, certain medications, exposure to some chemicals, etc.) and internal factors (hormone levels, genetic predisposition, ageing, inflammatory processes, etc.) that give rise to different clinical manifestations:

• Melasma is the most severe and resistant hyperpigmentation, and it is mainly associated with hormonal factors. It can appear following pregnancy or hormone treatments, such as contraceptives or hormone replacement therapy.

• Solar and senile lentigo is the hyperpigmentation associated with photoageing. They increase with age and usually appear in areas of the skin exposed to the sun, such as the face, neck and hands.

• Post-inflammatory hyperpigmentation (PIH) are injuries caused by inflammation, such as scarring, acne marks, or after applying certain therapeutic procedures.

• Ephelides or freckles are small brown hyperpigmentations that appear on the skin exposed to the sun, which darkens it. They have a genetic component and mainly affect people with clear phototype.

dermamelan® method

dermamelan® is the depigmenting method that provides an intensive corrective action on skin hyperpigmentations while regulating melanin overproduction in melanocytes, inhibiting and controlling reappearance of new spots. It acts at two levels, corrective and regulatory, achieving a short and long-term result to maintain hyperpigmentations under control.

The dermamelan® method consists of a protocol comprising 4 phases which are necessary to achieve the target outcome. Intensive depigmentation in office in phase 1 and treatment for home use in phases 2, 3 and 4.

action of dermamelan®

dermamelan® formula has a unique combination of active ingredients of proven efficacy,1-6 that act on all phases of the hyperpigmentation process to remove totally the existing hyperpigmentations and prevent their reappearance, as well as the appearance of new spots.


It speeds up the skin renewal process, forcing shedding and removing effectively melanin deposits. Reduces the amount of melanin formed, thus decreasing the intensity of the spot.


It blocks melanosome transfer to keratinocytes to prevent melanin migration to the outermost skin layers.Reduces the activation of tyrosinase, as it contains copper (Cu2+) chelating active ingredients Reduces the oxidising reactions of tyrosine, neutralising free radicals. Inhibits the tyrosinase enzyme, neutralising its action This dual corrective and regulating action makes it a unique, all-round treatment.

Treatment results

Before Before
Melasma (phototype III)
Before Before
Melasma (phototype III)

dermamelan® Products