skinretin 0,3%

cream with retinol


Cream including pure retinol and bakuchiol with a global anti-ageing action to treat wrinkles, spots, loss of luminosity and skin elasticity.
50 ml

Cream that combines pure retinol and bakuchiol with an intensive regenerating and renewing action. Rejuvenates, brightens and revitalises skin.

Intensive night cream to treat signs of ageing: - Irregular tone and loss of luminosity - Deep wrinkles and expression lines - Loss of skin density and elasticity

Dermatologically tested formula. Backed by clinical and in vitro studies.

After 28 days, our volunteers reported: - 50%+ reduction of wrinkles¹ - 70%+ better skin texture¹

Night cream with light texture, suitable for all skin types.

The combination of pure retinol and bakuchiol maximises the formula's anti-ageing benefits and promotes an optimal balance in terms of tolerance. In addition, by incorporating our exclusive post-biotic complex, we reinforce the skin's renewal capacity while respecting and strengthening the skin microbiota.

¹In vitro studies demonstrated the efficacy in terms of cell renewal, with an acceleration in the regeneration rate 9.8 times higher.


centella asiatica


Treatment area face.
frequency of use occasional.
time of use evening.
Clock occasional, evening.

Apply at night to clean, dry skin on the face, neck and neckline.

Use every other day during the first 2 weeks. Retinol can cause mild flaking and skin sensitivity. This is normal and expected. If the tolerance to the product is good, apply daily. If not, apply less frequently. In the daytime, complement the treatment with an SPF50+ sunscreen.

Product category home
Age all
Routine stage treatment
Type of skin all
indication Global anti-ageing night cream. Rejuvenates, brightens and revitalises skin.
Treatment area face
See more

skinretin 0,3%

visible results after 28 days of use¹


reduction of wrinkles


improvement in elasticity


better skin texture


more elastic, brighter, firmer and smoother skin


very good tolerability

results before and after

Before Before
Before Before

what is skinretin 0.3%? and its benefits

Spots, expression lines, wrinkles and loss of firmness are the most common manifestations of skin aging.

skinretin 0.3% is an intensive solution that achieves maximum anti-aging efficacy and maintains an optimal balance in terms of skin tolerance

Formula and texture suited to all skin types to combat signs of aging.

main ingredients in skinretin 0.3%

global anti-aging action

A combination that maximises the formula's anti-aging potential and maintains high tolerance levels.

0,3% pure retinol

0,7% bakuchiol

Regenerative and rebalancing action

It enhances regeneration and stimulates the skin microbiota, favouring an optimal barrier function.

post-biotic complex

how to use retinol for the first time

use it at night

Start by applying it on alternate nights. If you have sensitive skin, you can space the applications at the beginning of the treatment.
Apply skinretin 0.3% on clean, dry skin, avoiding the eye contour.

From the second week onwards, tolerance will be good, so you can increase the frequency of applications

during the day

Do not use skinretin 0.3%, apply it only at night, and don't forget to use sunscreen.

Mild dryness, slight irritation and little scaling may occur in the first applications These effects are due to the process of your skin adapting to retinol; they are expected and temporary.

It reinforces the restorative and moisturising action in applications without skinretin 0.3% until your skin has become accustomed to retinol

skinretin 0.3% application

efficacy endorsed by science


cell proliferation²


It favours the proliferation of fibroblasts, the cells responsible for collagen and elastin synthesis.


without skinretin control

control 11 cells

with skinretin control

with skinretin 0.3% 108 cells


epidermal thickness²

renews the skin

Increases the expression of cytokeratin 14, fluorescent green marker, an indicator of optimal skin renewal


without skinretin 0.3%

control: green: cytokeratin 14

with skinretin 0.3%

skinretin 0.3%

FAQ skinretin 0,3%

can I use retinol if I have sensitive skin?

skinretin 0.3% is recommended for all skin types. If your skin is sensitive, in first applications apply a moisturising cream or restorative serum before applying retinol. You can also space the application further at the beginning, leaving a two-night interval in the first week. You will be able to gradually increase the frequency of application.

what should I do if my skin suffers scaling, dryness or irritation?

Mild dryness, slight irritation and little scaling may occur. These effects are due to the process of your skin adapting to retinol; they are expected and temporary. If irritation persists, temporarily suspend the treatment.

is it normal for skin to get irritated in the first applications?

Yes, your skin is being renewed. Boost your daily routine with nourishing and restorative products to smoothen the effects of retinisation, and don't forget to use sunscreen.

at what age can a retinol treatment be initiated?

Products with retinol can be used from adolescence onwards; however, the anti-aging benefits of skinretin 0.3% are indicated for people over 30 years of age with emerging signs of aging.

can I apply retinol on the neck and neckline?

Yes, following the recommended application guidelines and respecting the retinisation process.
You must bear in mind that these are sensitive areas to which you must pay special attention.

if I use a treatment with tranexamic acid, how can I incorporate retinol?

We recommend a progressive retinisation on alternate nights, and once the skin shows good retinol tolerance, we can start incorporating tranexamic acid on nights in which retinol is not applied.

is it advisable to apply a serum before skinretin 0.3%?

You can apply any moisturising or restorative serum, but we recommend applying it on its own. If your skin is sensitive, using a serum beforehand will soften the effects of retinisation.

retinol: what is it and what are its benefits?

Find out more about retinol on our blog, see more here

¹ Medical Affairs Unit. MESO_0822 studies to assess the safety, efficacy and tolerance of the cosmetic product skinretin 0.3%. mesoestetic Pharma Group S.L. 2022

² Biotechnology Unit Wound healing trial on fibroblasts with Retinol + Bakuchiol + Post-biotic complex mesoestetic Pharma Group S.L. 2022