
cosmelan®
depigmenting solution by mesoestetic®
cosmelan®incorporates a protocolized professional treatment to optimize the results and the home maintenance that prolongs the results. The duality of corrective and regulating action, make it a unique, all-round treatment. The cosmelan® formula contains an exclusive combination of active ingredients with proven efficacy, which act on all stages of the hyperpigmentation process to completely eliminate existing hyperpigmentations, preventing both their reappearance and the appearance of new dark spots. A comprehensive and effective result.
Science and results
Scientific aspects of skin spots
Incidence and factors for apparition
Pigmentation concerns are a growing, global issue; they affect more than 90% of adults over the age of 50. Regardless of skin color, they are a significant issue because of their unattractive appearance and negative psychological and emotional impact, affecting quality of life. Numerous external and internal factors can cause hyperpigmentation:
- Genetic tendency
- Sun exposure
- Inflammation
- Hormonal changes
- Aging
- Exposure to chemicals
- Photosensitizing medication
Types of hyperpigmentation and their diagnosis
Melasma
Melasma has an uneven and irregular shape with undefined edges. Often symmetric, shadow-like appearance. They appear in the center of the face, malar area and jaw. Some 90% of those affected are women, particularly those who are pregnant, taking contraceptives or hormone replacement therapy (HRT).

Postinflammatory hyperpigmentation (PIH)
This appears as irregular, flat, asymmetric spots of dark pigmentation, either localized or dispersed. They appear throughout the body and face. This condition is more common in dark phototypes. After: skin lesions (acne or dermatitis), aggressions (burns, surgery, traumas), aesthetic treatments (chemical peels, laser), upper lip hair removal, photosensitizing medicines.

Solar and senile lentigo
Appearing in the form of uniform, lentil-shaped oval or round spots, which measure between 2-20 millimeters in diameter; they appear on the face, hands, shoulders, arms, back and neckline. The senile lentigo affects persons of + 50 years, due to the accumulated effect of the sun. Solar lentigo affects persons over 30, often in low phototype skins.

Ephelides (freckles)
Small macules, flat and pigmented, multiple and symmetrical, light brown in color. They appear in the T area, cheekbones, cheeks, neckline and back of the arms. Commonly affects low phototypes, with fair skin and blonde or red hair. Highly sensitive to UV radiation.

Cosmelan® method
Trust the world’s No. 1
cosmelan® is the world-leading professional depigmentation method for many reasons:
- Proven efficacy. Study results endorse its effectiveness in any skin phototype (I-VI) and all ethnic groups
- High satisfaction. Excellent long-term results and a high level of satisfaction for the treated patient.
- + 1 million patients More than 1 million patients treated1
- International presence Distributed on 5 continents1
- Satisfied professionals. Thousands of professionals already use it and recommend it to their patients
Unique and integral treatment
Stages
The method comprises 4 treatment stages, full compliance of which ensures excellent results for the patient.
- Intense depigmentation
- Continuous depigmentation
- Control of hyperpigmentation
- Control of reappearance

Professional care, treatment room guideline
The method starts in a salon at the hands of a professional who, strictly following the protocol, applies the desgreasing solution and face mask. Once the mask has been applied the patient can return home. During the application time and after removing the mask, the patient must avoid exposure to sources of light and heat. At the end of the time specified by the professional, the patient must remove the cosmelan 1 mask at home, carefully cleansing the application area with plenty of lukewarm water. Never exceed the recommended application time.
Home care, guideline at home
The method continues at home 48 hours after removing the mask. The patient must follow the steps indicated at each stage to ensure the desired result. The complete home treatment lasts for 7 months and consistency and perseverance are essential to ensure the guaranteed results.
Formula and results
The cosmelan® formula contains an exclusive combination of active ingredients with proven efficacy, which act on all stages of the hyperpigmentation process to completely eliminate existing hyperpigmentations, preventing both their reappearance and the appearance of new dark spots.
Regulating action
cosmelan® works at two levels: At the first level by inhibiting the activation of tyrosinase inside the melanosome, reducing the oxidative stress, and thereby reducing melanin synthesis; at a second level, by containing copper chelators (Cu2+) tyrosinase function is reduced. Cosmelan® acts by blocking the transfer of the melanosome to the keratinocytes, thereby preventing movement of the pigment to the superficial layers of the skin.
Corrective action
It acts by reducing the amount of melanin synthesized, reducing the intensity of the dark spot. It also acts on the stratum corneum, stimulating the renewal of the epidermis and intensively eliminating the accumulation of melanin.